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This book provides a detailed overview of the progress and
challenges of non-traditional approaches for tackling antimicrobial
resistance. The first chapter covers the factors that make microbes
more likely to develop multidrug resistance. The book goes on to
discuss the antimicrobial properties of propolis, essential oils
and other microbial constituents that are used or under
investigation to treat multidrug-resistant infections.
Additionally, it covers alternative compounds that work as
antimicrobial agents, their mechanisms of action, and how they
might be utilized in conjunction with conventional drugs to
circumvent drug resistance. The book explores the application of
phage therapy and recent advancements in phage-based infection
control with an emphasis on multidrug-resistant infections and
discusses drug repurposing as a strategy to develop new
antimicrobial agents efficiently and expeditiously. Additionally,
it discusses the uses of nanoparticles in the treatment of
infections brought on by multidrug-resistant pathogens and examines
the use of different nanotechnology-based approaches to fudge
microbial resistance mechanisms. It concludes by reviewing recent
studies on microbial quorum-sensing systems and focuses on the
significance of quorum-sensing systems in controlling microbial
resistance mechanisms and at the same time highlights the
importance and role of antimicrobial stewardship program to fight
microbial infections. The book is an invaluable source of knowledge
and information for academics, basic and clinical researchers,
clinicians, and paramedic staff involved in one way or the other in
the development and use of antimicrobial agents and strategies to
combat multidrug resistance.
Combination Therapy against Multidrug Resistance explores the
potential of combination therapy as an efficient strategy to combat
multi-drug resistance. Multidrug resistance (MDR) occurs when
microorganisms such as bacteria, fungi, viruses, and parasites are
excessively exposed to antimicrobial drugs such as antibiotics,
antifungals, or antivirals, and in response the microorganism
undergoes mutations or develops different resistance mechanisms to
combat the drug for its survival. MDR is becoming an increasingly
serious problem in both developed and developing nations. Bacterial
resistance to antibiotics has developed faster than the production
of new antibiotics, making bacterial infections increasingly
difficult to treat, and the same is true for a variety of other
diseases. Combination therapy proves to be a promising strategy as
it offers potential benefits such as a broad spectrum of efficacy,
greater potency than the drugs used in monotherapy, improved safety
and tolerability, and reduction in the number of resistant
organisms. This book considers how combination therapy can be
applied in multiple situations, including cancer, HIV,
tuberculosis, fungal infections, and more. Combination Therapy
Against Multidrug Resistance gathers the most relevant information
on the prospects of combination therapy as a strategy to combat
multridrug resistance and helping to motivate the industrial sector
and government agencies to invest more in research and development
of this strategy as a weapon to tackle the multidrug resistance
problem. It will be useful to academics and researchers involved in
the development of new antimicrobial or antiinfective agents and
treatment strtategies to combat multidrug resistance. Clinicians
and medical nurses working in the field of infection prevention and
control (IPC) will also find the book relevant
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